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Study Shows Why Protein-Rich Meals Are More Effective At Promoting Wakefulness

January 17, 2012: 12:00 AM EST
A British study has found that activity in the brain’s orexin/hypocretin neuron system – which controls energy balance and wakefulness – is regulated by macronutrient balance rather than simply by the caloric content of the diet. This cellular mechanism allows brain cells to translate different diets into different patterns of activity. The orexin/hypocretin neurons are apparently under a “push-pull” control by sugars and proteins, a finding that is consistent with reports that when compared with sugar-rich meals, protein-rich meals are more effective at promoting wakefulness and arousal.
Mahesh M. Karnani et al., "Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids", Neuron, January 17, 2012, © Elsevier Inc.
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