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Aspirin Reduces Risk Of Colon Cancer In Obese Patients With Lynch Syndrome

August 22, 2015: 12:00 AM EST
Overweight people with an inherited genetic disorder known as Lynch syndrome can reduce the risk of colorectal cancer by taking 600 mg of aspirin daily, a British study has found. Being overweight more than doubles the risk of bowel cancer in people with the syndrome, which affects genes responsible for repairing DNA damage. Half of these people develop bowel or womb cancer. The randomized controlled trial is a multicenter, multinational study involving a thousand Lynch syndrome patients. A daily aspirin dose of 600 mg removed most of the increased risk associated with higher BMI. The researchers said further study is needed to confirm the protective power of aspirin with respect to BMI.
Mohammad Movahedi et al., "Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study. ", Journal of Clinical Oncology, August 22, 2015, © American Society of Clinical Oncology
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