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Body’s Circadian Rhythms Upset By High-Fat Diet, Causing Metabolic Problems

December 19, 2013: 12:00 AM EST
The circadian clock – the internal body clock that regulates metabolic functions in the liver – can reprogram itself depending on the nutritional content, especially the fat content, of a person’s diet, U.S. researchers report. The day-night pattern of circadian rhythms affects about 15 percent of human genes, including those involved with metabolic pathways in the liver. A high-fat diet reprograms the liver clock, contributing to ailments such as diabetes, obesity and high blood pressure. The researchers noted, however, that returning to a balanced, low-fat diet normalizes the rhythms. The findings could lead to the discovery of drug targets for controlled diets.
Kristin L. Eckel-Mahan et al., "Reprogramming of the Circadian Clock by Nutritional Challenge", Cell, December 19, 2013, © Elsevier Inc.
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