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Compounds Left In Gut After Wine Digestion Protect Neuronal Cells

May 5, 2017: 12:00 AM EST
Scientists have known for years that drinking wine in moderation seems to delay the onset of brain disorders and cognitive impairment associated with aging. A multinational research team investigating the phenomenon has come up with some tentative insights into why this happens. They didn’t examine the wine itself, but took a close look at the compounds – they’re called wine-derived human gut metabolites – that remain after the wine exits the stomach and enters the gut. Wine metabolites with the right composition were found to protect neuronal cells from stress, but only if the composition of the gut microbiota (i.e., probiotic profile) was just right.
A. Esteban-Fernández et al., "Neuroprotective Effects of Selected Microbial-Derived Phenolic Metabolites and Aroma Compounds from Wine in Human SH-SY5Y Neuroblastoma Cells and Their Putative Mechanisms of Action", Frontiers in Nutrition, May 05, 2017, © Esteban-Fernández et al.
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