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Drug Combo Effective At Preventing Colon Cancer

March 30, 2015: 12:00 AM EST
Promising results from animal studies have convinced U.S. researchers to plan clinical trials testing metformin and vitamin D3 combined for the prevention, and even treatment, of colorectal cancer. The prospects for such trials are good because both compounds have already been tested separately for safety. In experiments involving two animal models, metformin and vitamin D3 together were much more potent in preventing new colon tumors than either one alone. The researchers also found that it is not necessary to take huge doses of the drugs to prevent cancer. If the results translate to humans, “that will be a highly significant finding in colorectal cancer prevention."
Wan Li et al., "Combined Use of Vitamin D3 and Metformin Exhibits Synergistic Chemopreventive Effects on Colorectal Neoplasia in Rats and Mice", Cancer Prevention Research, March 30, 2015, © Li et al.
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