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Green Tea Molecule May Provide Therapy For Alzheimer’s Disease

March 5, 2013: 12:00 AM EST
In a laboratory study, U.S. researchers have found that specific molecules in green tea extract control the generation of metal-associated amyloid-β aggregates associated with Alzheimer's disease. Epigallocatechin-3-gallate, also known as EGCG, prevented aggregate formation and broke down existing aggregate structures in the proteins that contained copper, iron and zinc. The research team – including chemists, biochemists and biophysicists – next plan to test the green tea molecule's ability to inhibit potential toxicity of aggregates containing proteins and metals in fruit flies.
S.-J. Hyung et al., "Insights into antiamyloidogenic properties of the green tea extract epigallocatechin-3-gallate toward metal-associated amyloid species.", Proceedings of the National Academy of Sciences, March 05, 2013, © National Academy of Sciences
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