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No Evidence From Trials That Vitamin D Supplements Improve Depression Symptoms

March 18, 2014: 12:00 AM EST
Data from a systematic review of seven clinical trials involving 3,200 depression patients showed that vitamin D supplementation did little or nothing to improve symptoms. The U.S. researchers did find some hints in the data that vitamin D supplements may help patients with clinically significant depression, especially when combined with traditional antidepressant medication. The authors noted, however, that vitamin D supplements may be effective only for those who are already vitamin D deficient, and that future studies should consider how vitamin D dosing and mode of delivery affect depression.
J. A. Shaffer et al., "Vitamin D Supplementation for Depressive Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ", Psychosomatic Medicine, March 18, 2014, © American Psychosomatic Society
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