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Overeating Impairs The Brain’s Ability To Detect Insulin Signals, Which Can Lead To Diabetes

October 16, 2012: 12:00 AM EST
A U.S. study in animals has found a connection between overeating and a brain malfunction associated with poor insulin control and eventually diabetes. Overeating impairs the ability of brain insulin to suppress glucose release from the liver and lipolysis in fat tissue. When a person  overeats, the brain becomes unresponsive to important clues such as insulin, which then leads to diabetes. According to the researchers, the study shows “that it is really the brain that is harmed first [in overeating] which then starts the downward spiral."
T. Scherer et al., "Short Term Voluntary Overfeeding Disrupts Brain Insulin Control of Adipose Tissue Lipolysis", Journal of Biological Chemistry, October 16, 2012, © American Society for Biochemistry and Molecular Biology, Inc.
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