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Researchers Discover Possible Therapeutic Target For Type 2 Diabetes

March 19, 2014: 12:00 AM EST
U.S. researchers have found that by controlling levels of fat molecules called phosphatidic acids in the liver, it may be possible to reduce glucose production and control high blood sugar. The  University of Texas scientists, experimenting with mice, believe their findings could lead to the development of a drug that would help the estimated 25 million Americans with type 2 diabetes. In addition, the researchers believe their findings may help understand how cancer develops, because increased phosphatidic acid levels may play an important role in a metabolic pathway that supplies energy to cancer cells.
S. Sankella et al., "Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2-/- Mice. ", Journal of Biological Chemistry, March 19, 2014, © The American Society for Biochemistry and Molecular Biology, Inc.
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