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Two Antioxidants Reduce Heart Damage From Anti-Cancer Drug

July 16, 2015: 12:00 AM EST
Research has associated the powerful polyphenol antioxidant resveratrol, found in red wine, with a reduced risk of heart disease despite a high-fat diet. Now U.S. researchers have found that resveratrol, along with the polyphenol quercetin, may also prove to be a potent anti-cancer treatment. They developed a system to make the two water soluble and thus injectable into the blood stream. Levels in the body would thus be much higher than by eating the right foods or taking supplements. The two compounds appear to reduce the cardiac toxicity of the widely used cancer drug Adriamycin, which unfortunately can only be used for a limited time in humans. Administering the two polyphenols at the same time as Adriamycin might make it safer and increase its effectiveness.
Brianna Cote et al., "Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. ", Journal of Controlled Release, July 16, 2015, © Elsevier B.V.
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