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Vitamin A Derivative Shows Potential In Fighting Obesity, Diabetes

June 16, 2014: 12:00 AM EST
Canadian researchers have demonstrated in mice the benefits of using retinoic acid, a derivative of vitamin A, in treating obesity and type 2 diabetes. The study found that retinoic acid reduced the risk of cardiac apoptosis (cell death) in obese and insulin-resistant mice, stimulated the expression of cardio-protective genes reduced by the disease, and protected against the accumulation of collagen in heart muscle. Collagen accumulation is associated with fibrosis and future complications.  The scientists said the findings spotlight  new metabolic effects of retinoids and could lead to development of anti-obesity and anti-diabetic medicines.
Daniel-Constantin Manolescu et al., "All-trans retinoic acid stimulates gene expression of the cardio-protective natriuretic peptide system, and prevents fibrosis and apoptosis in cardiomyocytes of obese ob/ob mice. ", Applied Physiology, Nutrition, and Metabolism, June 16, 2014, © Canadian Science Publishing
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