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Coffee Compound Might Someday Offset Negative Impact Of Weight Gain

November 14, 2014: 12:00 AM EST
U.S. researchers who conducted a study in mice fed a high-fat diet found that chlorogenic acid (CGA), a compound found in coffee, significantly reduces insulin resistance and accumulation of liver fat. The mice received a dose of CGA that is much higher than what humans absorb through regular coffee consumption. But the researchers plan to study the possibillity of developing an improved CGA formulation specifically for human consumption that could form the basis of a therapeutic to offset the negative effects of excessive weight gain -- including diabetes and heart disease.
Yongjie Ma et al., "Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. ", Pharmaceutical Research, November 14, 2014, © Springer International Publishing AG
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