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Genes That Regulate Heart Health Are Severely Impacted By Cigarette Smoke

July 10, 2013: 12:00 AM EST
Researchers who looked at why mainstream and sidestream smoke increases the risk of heart disease among obese people have found a genetic answer. Sidestream smoke – from the burning end of a cigarette, cigar, etc. – inhibits the activity of genes that protect the heart and lungs, and activates genes associated with an increased risk of heart disease. The U.S. study in mice is the first to examine how the heart responds to cigarette smoke in the context of a high-fat diet and obesity, and provides a first step toward finding a molecular basis for the damage to the heart and lungs caused by tobacco smoke inhalation.
Susan C. Tilton et al., "Impaired Transcriptional Response of the Murine Heart to Cigarette Smoke in the Setting of High Fat Diet and Obesity", Chemical Research in Toxicology, July 10, 2013, © American Chemical Society
Heart & Cardiovascular
North America
United States of America
Research, Studies, Advice
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