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More Fiber In Diet Is Good, Except When The Bacteria Control System Is Defective

November 13, 2015: 12:00 AM EST
Some studies have linked metabolic syndrome with the fermentation activities of bacteria on soluble fiber in the intestines. The bacteria digest the fiber, creating short chain fatty acids that control inflammation and reduce the risk of obesity. So it is usually healthful to increase fiber consumption. But a new U.S. study found a link between unchecked bacterial fermentation, increased short-chain fatty acids and increased liver lipids in people (and mice) with a compromised “TLR5” function. A defect in the TLR5 receptor reduces control of bacteria volumes. Bacteria multiply, lipids rise, as does the risk of non-alcoholic fatty liver disease and liver damage.
Vishal Singh et al. , "Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice", Cell Metabolism, November 13, 2015, © Elsevier B.V.
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