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Research Finds Splenda Lowers Gut Microflora, Increases Intestinal P-Glycoprotein

September 25, 2008: 04:22 PM EST
According to a study in the Journal of Toxicology and Environmental Health, Splenda may suppress beneficial bacteria in the gut and cause weight gain, even at consumption levels within FDA guidelines. A 12-week feeding study on rats suggests the sweetener also affects the expression of enzymes known to interfere with the absorption of nutrients and pharmaceuticals. The study was carried out by researchers from Duke University in North Carolina and co-sponsored by the Sugar Association. McNeil Nutritionals, the company behind Splenda, was quick to dismiss the study and draw attention to a number of other studies supporting the safety of the sweetener. It also questioned the methodology and the conclusions drawn by the researchers.
M. B. Abou-Donia et al, "Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats", Journal of Toxicology and Environmental Health, September 25, 2008, via PubMed, © Journal of Toxicology and Environmental Health
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