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Sensing the Presence of Sugar Key to Aging Process

March 5, 2009: 03:12 AM EST
A paper published in the journal PLoS Genetics explains how Université de Montréal scientists found that the presence of calories is not the important element in the aging process, but the extent to which cells sense them. There are two elements to calorie intake: taste and digestion. Cell sensors detect the presence of sugar glucose, for example, and molecules in the cell break it down, converting it to energy. Some thought the by-products in this process caused aging, but this study shows another possible cause, using yeast cells, which age much like human cells. The team found that the lifespan of yeast cells rises when glucose in the diet was reduced, but also found that: (a) cells that couldn’t consume glucose were still sensitive to the aging effects of glucose; and (b) eliminating the glucose sensor significantly increased lifespan.
"Over-consumption of sugar linked to aging", Nouvelles.com, March 05, 2009, © UdeMNouvelles
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