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Study Uncovers Key To Body’s Damaging Responses To Obesity

April 4, 2013: 12:00 AM EST
Japanese researchers have found in a mouse study that excess weight triggers the release of a compound in the bloodstream that in turn sparks the damaging immune responses associated with diabetes and heart disease. The researchers said it may be possible to stop the harmful autoimmune response by simply block the compound, known as  apoptosis inhibitor of macrophage (AIM). They suggested that AIM inhibition might someday be used as a therapy to prevent not only insulin resistance and metabolic disorders but also autoimmunity under obese conditions.
Satoko Arai et al., "Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells", Cell Reports, April 04, 2013, © Elsevier Inc.
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