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Synthetic Compound Reverses Fatty Liver Disease In Lab Tests

December 19, 2012: 12:00 AM EST
Researchers in the U.S. report development of a synthetic compound that reverses the effects of fatty liver disease, a condition that often accompanies obesity and type 2 diabetes. SR9238 suppressed lipid (fat) production in the liver, eliminated inflammation and reversed fat accumulation in lab animals. According to the researchers, mice fed a high-fat diet and the compound for a month reversed the disease without side effects. The researchers also noted that markers for liver damage were also down, so the compound may be a potential treatment for alcohol-related fatty liver damage.
Kristine Griffett et al., "A Liver Selective LXR Inverse Agonist that Suppresses Hepatic Steatosis", ACS Chemical Biology, December 19, 2012, © American Chemical Society
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