The circadian clock – the internal body clock that regulates metabolic functions in the liver – can reprogram itself depending on the nutritional content, especially the fat content, of a person’s diet, U.S. researchers report. The day-night pattern of circadian rhythms affects about 15 percent of human genes, including those involved with metabolic pathways in the liver. A high-fat diet reprograms the liver clock, contributing to ailments such as diabetes, obesity and high blood pressure. The researchers noted, however, that returning to a balanced, low-fat diet normalizes the rhythms. The findings could lead to the discovery of drug targets for controlled diets.
"Reprogramming of the Circadian Clock by Nutritional Challenge", Cell, December 19, 2013
Foods and drinks advertised on TV programs – both children’s and others – in 2009 were generally less nutritious than foods promoted during regular broadcast hours, according to a new U.S. study. Researchers analyzed Nielsen TV ratings data from 2009 to determine what kind of food advertising children were exposed to. They then analyzed the nutritional content of the foods advertised on shows with a child-audience share of 35 percent of greater. More than 84 percent of food and beverage ads seen by children, ages 2 to 11, on all programming touted products high in fats, sugars and sodium. On children's programming, more than 95 percent of ads were for products high in those unhealthy ingredients.
"Nutritional Content of Food and Beverage Products in Television Advertisements Seen on Children's Programming", Childhood Obesity, December 17, 2013
U.S. researchers have been awarded a patent for an antioxidant compound that, in mice, decreases obesity by breaking down triglycerides stored in fat tissue. The compound could someday be used to treat obesity and related disorders like type 2 diabetes in humans. According to the researchers, obese mice that ingested the compound lost 40 percent of their body weight. The next step is to figure out how the compound, MnTBAP, triggers cellular and molecular events that lead to the weight loss, the Skidmore College researchers say.
"Researchers Earn Patent of Use for Anti-obesity Compound", News release, Skidmore College (N.Y.), December 16, 2013
German scientists who investigated the prevalence of dietary supplement use among older people in the city of Augsburg found that those who took magnesium and vitamin were overdoing it. The data from men and women aged 65 and older showed that 54 percent of the women and 34 percent of the men take dietary supplements. In both sexes, scientists found, the ingested doses of magnesium and vitamin E frequently exceeded European Food Safety Authority tolerability standards. The doses were too high in 20 percent of the females and 33 percent of the males regularly taking magnesium and in 8 and 14 percent, respectively. Vitamin D, frequently recommended by doctors for this age group for bone health, was taken by relatively few older people.
"The use of dietary supplements among older persons in Southern Germany — Results from the KORA-age study", The Journal Of Nutrition, Health & Aging, December 13, 2013
What a man eats prior to the conception of his child can impact fetal and child development, according to a Canadian study in mice. Researchers compared the offspring of fathers with insufficient folate (vitamin B9) in their diets with the offspring of fathers whose diets contained sufficient levels. Paternal folate deficiency was associated with an increase – as much as 30 percent – in birth defects of various kinds in the offspring, compared to the offspring of mice whose fathers ate sufficient folate. Adequate folate – found in green leafy vegetables, cereals, fruit and meats – in a mother’s diet has long been known to prevent miscarriages and birth defects.
"Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes", Nature Communications, December 10, 2013
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The New York Times, December 27, 2013
The New York Times, December 21, 2013
The New York Times, December 18, 2013
Journal of Adolescent Health, December 16, 2013
Wall Street Journal, December 16, 2013
The New York Times Company, December 09, 2013
The New York Times Company, December 09, 2013
The New York Times, December 05, 2013
University of Colorado Cancer Center, December 04, 2013
The New York Times, December 04, 2013
University of Kentucky, December 02, 2013
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