Thanks to revised Institute of Medicine guidelines on vitamin D deficiency, far fewer children in the U.S. are considered to have insufficient or deficient levels of vitamin D, a U.S. study has found. According to the new guidelines, most people get sufficient vitamin D when their blood levels are at or above 20 nanograms per milliliter (ng/mL). (Other guidelines recommend vitamin D levels above 30 ng/mL). The study looked at vitamin D data from 2,877 U.S. children and adolescents ages 6 to 18, finding that under the Institute of Medicine guidelines, 10.3 percent of children ages 6 to 18, or 5.5 million, are at risk. Under previous guidelines, millions more children who had vitamin D levels between 20 and 30 ng/mL would have needed supplementation.
"Prevalence of risk of deficiency and inadequacy of 25-hydroxyvitamin D in US children: NHANES 2003–2006. ", Journal of Pediatric Endocrinology and Metabolism, March 25, 2014
Expectant mothers, and women who are trying to get pregnant, who are exposed to ultraviolet radiation may lose some of the health benefits of folate intake. An Australian study of 45 young healthy women aged 18 to 47 showed that high rates of sun exposure accounted for up to a 20 percent drop in folate levels. Folic acid is a B vitamin, and folate is found in green leafy vegetables, citrus fruits, legumes, etc. Folate has been found to reduce miscarriage and neural tube defects such as spina bifida in unborn babies. The women in the study who were most at risk were those outside between 10 a.m. and 3 p.m. with little sun protection.
"Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age. ", Journal of Photochemistry and Photobiology B: Biology, March 21, 2014
A study presented at a national dental meeting provides evidence that tooth and gum diseases, as well as other biosocial conditions, are closely associated with depression and anxiety. The study analyzed data on depression, anxiety and tooth loss collected in a 2010 telephone survey of 451,000 people aged 19 or older. Of the 76,292 eligible participants, 13.4 percent reported anxiety, 16.7 percent reported depression, and 5.7 percent reported total tooth loss. Careful cross-analysis found that people with dental anxiety often avoid dental care, while people who are depressed neglect their health, including dental health.
"Tooth loss linked to depression, anxiety", News release, study presented at the annual meeting of the American Association for Dental Research, March 20, 2014
U.S. researchers have found that by controlling levels of fat molecules called phosphatidic acids in the liver, it may be possible to reduce glucose production and control high blood sugar. The University of Texas scientists, experimenting with mice, believe their findings could lead to the development of a drug that would help the estimated 25 million Americans with type 2 diabetes. In addition, the researchers believe their findings may help understand how cancer develops, because increased phosphatidic acid levels may play an important role in a metabolic pathway that supplies energy to cancer cells.
"Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2-/- Mice. ", Journal of Biological Chemistry, March 19, 2014
Data from a systematic review of seven clinical trials involving 3,200 depression patients showed that vitamin D supplementation did little or nothing to improve symptoms. The U.S. researchers did find some hints in the data that vitamin D supplements may help patients with clinically significant depression, especially when combined with traditional antidepressant medication. The authors noted, however, that vitamin D supplements may be effective only for those who are already vitamin D deficient, and that future studies should consider how vitamin D dosing and mode of delivery affect depression.
"Vitamin D Supplementation for Depressive Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ", Psychosomatic Medicine, March 18, 2014
A U.S. study in mice found that chronic sleep loss may be more serious than previously thought, mainly because it may lead to irreversible damage to brain cells. Extended wakefulness in the lab animals led to significant loss of the locus coeruleus neurons essential for alertness and optimal cognition. The researchers stressed that more work needs to be done to determine whether a similar phenomenon occurs in humans and to determine how much sleep loss puts people at risk of neural injury.
"Extended Wakefulness: Compromised Metabolics in and Degeneration of Locus Ceruleus Neurons. ", Journal of Neuroscience, March 18, 2014
A British study finds that people who live or work near fast-food restaurants tend to be more obese than those whose access is more limited. The study, based on data from 5,442 adults aged 29-62, showed that when the three exposure possibilities (work, home and commute) were combined, there was a significant relationship between take-out exposure and food consumption. Those who lived or worked close to fast-food take-out outlets had higher body mass indexes. The researchers said that replacing fast-food restaurants with more healthful outlets probably wouldn’t work. But the food offered could be changed for the better because "in the food environment, what matters is the menu … not the venue”.
"Associations between exposure to takeaway food outlets, takeaway food consumption, and body weight in Cambridgeshire, UK: population based, cross sectional study. BMJ", BMJ, March 13, 2014
Life expectancy has increased steadily around the globe, but older people often lead lives plagued by mental and physical decline. Researchers in Japan report that one way to combat functional decline may be through greater consumption of animal protein. With aging, the ability to absorb and process protein deteriorates. In their seven-year study, the researchers analyzed questionnaire data from 1,007 people whose average age was 67 years. Tests determined higher-level functional abilities Men who consumed the most animal protein were 39 percent less likely to experience functional decline than those who ate the least animal protein. The association was not seen in women, nor were any benefits derived from eating plant protein in either sex.
"Animal Protein Intake Is Associated with Higher-Level Functional Capacity in Elderly Adults: The Ohasama Study", Journal of the American Geriatrics Society, March 11, 2014
Two recent studies from the U.S. and Australia, one in mice and one in humans, found evidence that diets high in protein can actually be harmful over the long run. Protein-rich diets do have their benefits: they contribute to weight loss and to normalization of blood sugar levels. But the study in mice, which tested various ratios of protein to carbohydrates, found that animals that ate higher ratios of protein were leaner, but shorter-lived. The 18-year clinical study in 6,381 adults found that people aged 50 to 65 whose diet included high levels of animal protein were at much greater risk of cancer death and overall mortality. However, people over 65 who ate more animal protein survived longer.
"The Risk of High-Protein Diets", The Wall Street Journal, March 10, 2014
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New York Times, March 19, 2014
Asia Food Journal, March 18, 2014
New York Times, March 17, 2014
ACS Chemistry of Life, March 16, 2014
The American Journal of Clinical Nutrition, March 12, 2014
Publications of the University of Eastern Finland, March 10, 2014
Nutraceuticals World, March 10, 2014
Annals of Family Medicine, March 10, 2014
The New York Times Magazine, March 09, 2014
The New York Times, March 08, 2014
ACS Chemistry for Life, March 05, 2014
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